Nanomagazine

Nanostructures modeled on moth eyes may enhance medical imaging

Using the compound eyes of the humble moth as their inspiration, an international team of physicists has developed new nanoscale materials that could someday reduce the radiation dosages received by patients getting X-rayed, while improving the resolution of the resulting images. Moth_eye  

The work, led by Yasha Yi-a professor of the City University of New York, who is also affiliated with Massachusetts Institute of Technology and New York University-was published in the journal, Optics Letters. Like their Lepidopteran cousins the butterflies, moths have large compound eyes, made up of many thousands of ommatidia-structures made up of a primitive cornea and lens, connected to photoreceptor cells. But moth eyes, unlike those of butterflies, are remarkably anti-reflective, bouncing back very little of the light that strikes them. The adaptation helps the insects be stealthier and less visible to predators during their nocturnal flights. Because of this feature, engineers have looked to the moth eye to help design more efficient coatings for solar panels and antireflective surfaces for military devices, among other applications.

(in the image below, (a)The self-assembly of SiO2 nanoparticles on the top of high index light extraction layer Si3N4, which is deposited on Lu2SiO5:Ce thin film. (b) The scanning electron microscope image of the improved bio-inspired moth eye nanostructures with certain degree roughness on the sidewall, which shows interesting nano-on-nano features. Credit: Optics Letters.)

Moth_eyes

Now Yi and his colleagues have gone a step further, using the moth eye as a model for a new class of materials that improve the light-capturing efficiency of X-ray machines and similar medical imaging devices. In particular, the researchers focused on so-called “scintillation” materials: compounds that, when struck by incoming particles (say, X-ray photons), absorb the energy of the particles and then reemit that absorbed energy in the form of light. In radiographic imaging devices, such scintillators are used to convert the X-rays exiting the body into the visible light signals picked up by a detector to form an image.

One way to improve the output (the intensity of light signals read by the detector, and thus the resolution of the resulting images) is to increase the input-that is, to use a higher x-ray dosage. But that’s not healthy for patients because of the increased levels of radiation. An alternative, Yi and colleagues figured, is to improve the efficiency with which the scintillator converts X-rays to light. Their new material does just that. It consists of a thin film, just 500 nanometers thick, made of a special type of crystal known as cerium-doped lutetium oxyorthosilicate. These crystals were encrusted with tiny pyramid-shaped bumps or protuberances made of the ceramic material silicon nitride.  Each protuberance, or “corneal nipple,” is modeled after the structures in a moth’s eye and is designed to extract more light from the film.

Between 100,000 to 200,000 of the protuberances fit within a 100 x 100 micrometer square, or about the same density as in an actual moth eye.  The researchers then made the sidewalls of the device rougher, improving its ability to scatter light and thus enhancing the efficiency of the scintillator. In lab experiments, Yi and colleagues found that adding the thin film to the scintillator of an X-ray mammographic unit increased the intensity of the emitted light by as much as 175 percent compared to that produced using a traditional scintillator.

The current work, Yi says, represents a proof-of-concept evaluation of the use of the moth-eye-based nanostructures in medical imaging materials. “The moth eye has been considered one of the most exciting bio structures because of its unique nano-optical properties,” he says, “and our work further improved upon this fascinating structure and demonstrated its use in medical imaging materials, where it promises to achieve lower patient radiation doses, higher-resolution imaging of human organs, and even smaller-scale medical imaging. And because the film is on the scintillator,” he adds, “the patient would not be aware of it at all.”

Yi estimates that it will take at least another three to five years to evaluate and perfect the film, and test it in imaging devices. “We will need to work with medical imaging experts and radiologists for this to be actually used in clinical practice,” he says.

The work was done in collaboration with Professors Bo Liu and Hong Chen of Tongji University in Shanghai.
Paper: “Giant light extraction enhancement of medical imaging scintillation materials using biologically inspired integrated nanostructures,” Optics Letters, Vol. 37, Issue 14, pp. 2808-2810 (2012).


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